Vitamin D, Hypercalciuria and Kidney Stones

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Vitamin D, Hypercalciuria and Kidney Stones

The estimated lifetime risk of nephrolithiasis is growing nowadays, and the formation of kidney stones is frequently promoted by hypercalciuria. Vitamin D, and especially its active metabolite calcitriol, increase digestive calcium absorption-as urinary calcium excretion is directly correlated with digestive calcium absorption, vitamin D metabolites could theoretically increase calciuria and pr...

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Water and Salt So030 Amousemodelof Saltwasting, Hypercalciuria and Kidney Stones

Introduction and Aims: Calcium nephrolithiasis is a complex disease with multiple pathogenetic mechanisms. The role of salt wasting and the subsequent volume depletion in the pathogenesis of hypercalciuria and kidney stone formation remains speculative. The only known monogenic disorder associated with salt wasting/volume depletion, hypercalciuria and nephrolithiasis/ nephrocalcinosis is Bartte...

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Urine with stones: nephrocalcinosis and vitamin D

Background Nephrocalcinosis (NC) refers to diffuse, fine, renal parenchymal calcification, as assessed by radiology or ultrasonography. In medullary NC, the calcification tends to occur in the area of the renal pyramids. It is typically associated with elevated urinary calcium, phosphate, and oxalate, or it can occur with alkaline urine. Any disorder that can lead to hypercalcemia or hypercalci...

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Vitamin C Does Not Cause Kidney Stones

There is no evidence that vitamin C causes kidney stones. Indeed, in some cases, high doses may be curative. (3) A recent, large-scale, prospective study followed 85,557 women for 14 years and found no evidence that vitamin C causes kidney stones. (4) There was no difference in the occurrence of stones between people taking less than 250 milligrams per day and those taking 1.5 grams or more. Th...

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Vitamin D and Kidney

After absorption from the gut or entry into the circulation from the skin, vitamin D is hydroxylated to 25(OH)D by 25-hydroxylase enzyme in the liver and then to 1í µí»¼,25(OH)D 3 (or calcitriol) by 1í µí»¼-hydroxylase enzyme in the kidney and in many cells. The hormonal or active form of vitamin D, that is, 1,25(OH) 2 D 3 acts through a nuclear receptor (VDR) to carry out its many functions. T...

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ژورنال

عنوان ژورنال: Nutrients

سال: 2018

ISSN: 2072-6643

DOI: 10.3390/nu10030366